Randomized Controlled Trials: Overview and Updates
Below are a list articles that addresses issues and/or new approaches to the conduct of randomized controlled trials:
Chavez-MacGregor, M., & Giordano, S. H. (2016). Randomized clinical trials and observational studies: is there a battle?. Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 34(8), 772-773.
Deaton, A., & Cartwright, N. (2018). Understanding and misunderstanding randomized controlled trials. Social Science & Medicine, 210, 2-21.
Fanaroff, A. C., Califf, R. M., & Lopes, R. D. (2020). New approaches to conducting randomized controlled trials. Journal of the American College of Cardiology, 75(5), 556-559.
Frieden, T. R. (2017). Evidence for health decision making - beyond randomized, controlled trials. New England Journal of Medicine, 377(5), 465-475.
These interventions typically contain a number of components that can include multiple control and experimental groups, numerous techniques for delivering the intervention, a variety of groups for receiving the intervention and variability in terms of outcomes being assessed.
Complex interventions pose a significant challenge for researcher by way of introduction of error. Below are a few suggested readings that address fundamental issues related to the design and implementation of complex interventions:
Horton, T. J., Illingworth, J. H., & Warburton, W. H. (2018). Overcoming challenges in codifying and replicating complex health care interventions. Health Affairs, 37(2), 191-197.
O'Cathain, A., Croot, L., Duncan, E., Rousseau, N., Sworn, K., Turner, K. M., ... & Hoddinott, P. (2019). Guidance on how to develop complex interventions to improve health and healthcare. BMJ open, 9(8), e029954.
Movsisyan, A. (2018). Applying GRADE in systematic reviews of complex interventions: Challenges and considerations for a new guidance (Doctoral dissertation, University of Oxford).
Paparini, S., Green, J., Papoutsi, C., Murdoch, J., Petticrew, M., Greenhalgh, T., ... & Shaw, S. (2020). Case study research for better evaluations of complex interventions: rationale and challenges. BMC medicine, 18(1), 1-6.
Tanner-Smith, E. E., & Grant, S. (2018). Meta-analysis of complex interventions. Annual Review of Public Health, 39, 135-151.