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Dr. Mario Clemente Estable

Associate Professor (on Sabbatical)
416-979-5000 Ext. 554517

Research Interests

Mapping the repressor regions of the MCEF protein, by mutagenesis; structure/ function analysis of MCEF; species-specific co-factors for HIV-1 transcription.

  • Modeling by disruption and a selected-for partner for the nude locus.
    Li J, Lee YK, Fu W, Whalen AM, Estable MC, Raftery LA, White K, Weiner L, Brissette JL.
    EMBO Rep. 2021 Mar 3;22(3):e49804. doi: 10.15252/embr.201949804. Epub 2020 Dec 28.
    PMID: 33369874
  • In search of a function for the most frequent naturally-occurring length polymorphism (MFNLP) of the HIV-1 LTR: retaining functional coupling, of Nef and RBF-2, at RBEIII?
    Estable MC
    Int J Biol Sci. 2007 Jun 11;3(5):318-27. doi: 10.7150/ijbs.3.318.
    PMID: 17589566
  • TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF.
    Chen J, Malcolm T, Estable MC, Roeder RG, Sadowski I.
    J Virol. 2005 Apr;79(7):4396-406. doi: 10.1128/JVI.79.7.4396-4406.2005.
    PMID: 15767439
  • MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription. Niedzielski MF, Hopewell R, Ismail Z, Estable MC.
    Int J Biol Sci. 2007 Mar 1;3(4):225-36. doi: 10.7150/ijbs.3.225.
    PMID: 17389929
  • MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.
    Estable MC
    , Naghavi MH, Kato H, Xiao H, Qin J, Vahlne A, Roeder RG.
    J Biomed Sci. 2002 May-Jun;9(3):234-45. doi: 10.1007/BF02256070.
    PMID: 12065898
  • The sequestration of miR-642a-3p by a complex formed by HIV-1 Gag and human Dicer increases AFF4 expression and viral production
    Sergio P. Alpuche-Lazcano, Owen R. S. Dunkley,  Robert J. Scarborough, Sylvanne M. Daniels, Aïcha Daher, Marin Truchi, Mario C. Estable, Bernard Mari, Andrew J. Mouland, Anne Gatignol
    doi: (external link) 
Degree University
PDF Rockefeller University
PhD University of British Columbia
MSc Université Laval
BSc University of Ottawa